Basic Research

  1. Guo, J.H., Chen, H., Ruan, Y.C., Zhang, X.L., Zhang, X.H., Fok, K.L., Tsang, L.L., Yu, M.K., Huang, W.Q., Sun, X., Chung, Y.W., Jiang, X., Sohma, Y., & Chan, H.C. (2014). Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR. Nature Communications, 5, 4420. https://doi.org/10.1038/ncomms5420

  2. Ruan, Y.C., Guo, J.H., Liu, X., Zhang, R., Tsang, L.L., Dong, J.D., Chen, H., Yu, M.K., Jiang, X., Zhang, X.H., Fok, K.L., Chung, Y.W., Huang, H., Zhou, W.L., & Chan, H.C. (2012). Activation of the epithelial Na(+) channel triggers prostaglandin E(2) release and production required for embryo implantation. Nature Medicine. https://doi.org/10.1038/nm.2771
    *Co-first authors

  3. Sun, X., Guo, J.H., Zhang, D., Chen, J.J., Lin, W.Y., Huang, Y., Chen, H., Huang, W.Q., Liu, Y., Tsang, L.L., Yu, M.K., Chung, Y.W., Jiang, X., Huang, H., Chan, H.C., & Ruan, Y.C. (2018). Activation of the epithelial sodium channel (ENaC) leads to cytokine profile shift to pro-inflammatory in labor. EMBO Molecular Medicine, 10(10), e8868. https://doi.org/10.15252/emmm.201808868
    *Co-first authors

  4. Huang, W.Q., Guo, J.H., Zhang, X.H., Yu, M.K., Chung, Y.W., Ruan, Y.C., & Chan, H.C. (2017). Glucose-Sensitive CFTR Suppresses Glucagon Secretion by Potentiating KATP Channels in Pancreatic Islet α Cells. Endocrinology, 158(10), 3188-3199. https://doi.org/10.1210/en.2017-00262
    *Co-first authors

  5. Zhang, X.L., Zhao, X., Wu, Y., Huang, W.Q., Chen, J.J., Hu, P., Liu, W., Chen, Y.W., Hao, J., Xie, R.R., Chan, H.C., Ruan, Y.C., Chen, H., & Guo, J.H. (2022). Angiotensin (1-7) activates MAS-1 and upregulates CFTR to promote insulin secretion in pancreatic β-cells: the association with type 2 diabetes. Endocrine Connections, 11(1), e210357. https://doi.org/10.1530/EC-21-0357

  6. Liu, Z., Guo, J., Wang, Y., Weng, Z., Huang, B., Yu, M.K., Zhang, X., Yuan, P., Zhao, H., Chan, W.Y., Jiang, X., & Chan, H.C. (2017). CFTR-β-catenin interaction regulates mouse embryonic stem cell differentiation and embryonic development. Cell Death & Differentiation, 24(1), 98-110. https://doi.org/10.1038/cdd.2016.118

  7. Chen, H., Guo, J.H., Lu, Y.C., Ding, G.L., Yu, M.K., Tsang, L.L., Fok, K.L., Liu, X.M., Zhang, X.H., Chung, Y.W., Huang, P., Huang, H., & Chan, H.C. (2012). Impaired CFTR-dependent amplification of FSH-stimulated estrogen production in cystic fibrosis and PCOS. Journal of Clinical Endocrinology & Metabolism, 97(3), 923-932. https://doi.org/10.1210/jc.2011-2553

Interdisciplinary Research

  1. Guo, J.#, Wu, Y., Gong, Z., Chen, X., Cao, F., Kala, S., Qiu, Z., Zhao, X., Chen, J.J., He, D., Chen, T., Zeng, R., Zhu, J., Wong, K.F., Murugappan, S., Zhu, T., Xian, Q., Hou, X., Ruan, Y.C., Li, B., Li, Y.C., Zhang, Y., & Sun, L. (2022). Photonic Nanojet-Mediated Optogenetics. Advanced Science, 9(7), 2104140. https://doi.org/10.1002/advs.202104140

  2. Qiu, Z., Kala, S., Guo, J., Xian, Q., Zhu, J., Zhu, T., Hou, X., Wong, K.F., Yang, M., Wang, H., & Sun, L. (2020). Targeted Neurostimulation in Mouse Brains with Non-invasive Ultrasound. Cell Reports, 32(7), 108033. https://doi.org/10.1016/j.celrep.2020.108033
    *Co-first authors

  3. Qiu, Z., Guo, J., Kala, S., Zhu, J., Xian, Q., Qiu, W., Li, G., Zhu, T., Meng, L., Zhang, R., Chan, H.C., Zheng, H., & Sun, L. (2019). The Mechanosensitive Ion Channel Piezo1 Significantly Mediates In Vitro Ultrasonic Stimulation of Neurons. iScience, 21, 448-457. https://doi.org/10.1016/j.isci.2019.10.037
    *Co-first authors

  4. Chen, X., Wu, T., Gong, Z., Guo, J., Liu, X., Zhang, Y., Li, Y., & Ferraro, P., Li, B. Lipid droplets as endogenous intracellular microlenses. Light: Science & Applications, 10(1), 1-11. https://doi.org/10.1038/s41377-021-00486-w

  5. Wu, T., Chen, X., Gong, Z., Yan, J., Guo, J., Zhang, Y., Li, Y., & Li, B. (2021). Intracellular Thermal Probing Using Aggregated Fluorescent Nanodiamonds. Advanced Science, 8(23), 2103354. https://doi.org/10.1002/advs.202103354

  6. Gong, Z., Wu, T., Chen, X., Guo, J., Zhang, Y., & Li, Y. (2021). Upconversion Nanoparticle Decorated Spider Silks as Single-Cell Thermometers. Nano Letters, 21(3), 1469-1476. https://doi.org/10.1021/acs.nanolett.0c04918

  7. Hou, X., Qiu, Z., Xian, Q., Kala, S., Jing, J., Wong, K.F., Zhu, J., Guo, J., Zhu, T., Yang, M., & Sun, L. (2021). Precise Ultrasound Neuromodulation in a Deep Brain Region Using Nano Gas Vesicles as Actuators. Advanced Science, 8(21), 2101934. https://doi.org/10.1002/advs.202101934